TADs Pair Homologous Chromosomes to Promote Interchromosomal Gene Regulation
نویسندگان
چکیده
منابع مشابه
Interchromosomal association and gene regulation in trans.
The nucleus is an ordered three-dimensional entity, and organization of the genome within the nuclear space might have implications for orchestrating gene expression. Recent technological developments have revealed that chromatin is folded into loops bringing distal regulatory elements into intimate contact with the genes that they regulate. Such intrachromosomal contacts appear to be a general...
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Enchanced survival of ultraviolet-irradiated Escherichia coli dependent upon the recA + gene appears to result from the ability to seal gaps in newly synthesized deoxyribonucleic acid (DNA) produced when DNA containing pyrimidine dimers is replicated (8). Strains which are recombination-deficient (recA) do not seal these gaps and degrade their DNA to a considerable extent. Rupp and Howard-Fland...
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Haploid Saccharomyces can change mating type through HO-endonuclease cleavage of an expressor locus, MAT, followed by gene conversion using one of two repository loci, HML or HMR, as donor. The mating type of a cell dictates which repository locus is used as donor, with a cells using HML and alpha cells using HMR. This preference is established in part by RE, a locus on the left arm of chromoso...
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Cell cycle checkpoints sense defects in chromosome metabolism, halt the cell cycle, and activate pathways that repair the defects. The spindle checkpoint arrests the cell cycle in response to defects in the interaction between microtubules and kinetochores (the proteinaceous complex assembled on centromeric DNA), but no repair function has been demonstrated for this checkpoint. We show that the...
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Reduction in chromosome number and genetic recombination during meiosis require the prior association of homologous chromosomes, and this has been assumed to be a central event in meiosis. Various studies have suggested, however, that while the reduction division of meiosis is a universally conserved process, the pre-meiotic association of homologues differs among organisms. In the fruit fly Dr...
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ژورنال
عنوان ژورنال: SSRN Electronic Journal
سال: 2018
ISSN: 1556-5068
DOI: 10.2139/ssrn.3275293